Mesenchymal stem cells and cancer therapy: insights into targeting the tumour vasculature.

ABSTRACT: A crosstalk established between tumor microenvironment and tumor cells leads to contribution or inhibition of tumor progression. Mesenchymal stem cells (MSCs) are critical cells that fundamentally participate in modulation of the tumor microenvironment, and have been reported to be able to regulate and determine the final destination of tumor cell. Conflicting functions have been attributed to the activity of MSCs in the tumor microenvironment; they can confer a tumorigenic or anti-tumor potential to the tumor cells. Nonetheless, MSCs have been associated with a potential to modulate the tumor microenvironment in favouring the suppression of cancer cells, and promising results have been reported from the preclinical as well as clinical studies. Among the favourable behaviours of MSCs, are

SUBMITTER: Aravindhan S 

PROVIDER: S-EPMC7938588 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature