Acquisition of cancer stem cell capacities after spontaneous cell fusion.

ABSTRACT:

Background

Cancer stem/Initiating cell (CS/IC) hypothesis argues that CS/ICs are responsible of tumour initiation, drug resistance, metastasis or disease relapse. Their detection in several cancers supports this concept. However, their origin is still misunderstood. Cell fusion is shown to take part in the formation of CS/ICs, i.e. fusion between mesenchymal stem cell and cancer cell. In a previous paper, we described that fusion leads to hybrids with metastatic capacity. This process triggered genomic rearrangements in hybrid cells together with increased metastasis development. Here, we hypothesize that cell fusion could be strong enough to provoke a cellular reprogramming and the acquisition of CS/IC properties, promoting metastasis formation.

Methods

After spontaneous ce

SUBMITTER: Merle C 

PROVIDER: S-EPMC7938600 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature