Acquired von Willebrand syndrome in monoclonal gammopathy - A scoping review on hemostatic management.

ABSTRACT:

Background

Acquired von Willebrand syndrome (AVWS) has been associated with monoclonal gammopathy of undetermined significance (MGUS), with limited data on its management.

Methods

We conducted a systematic literature search in Medline (Ovid), Embase, and Scopus up to September 11, 2019, for studies reporting on the management of AVWS associated with MGUS (AVWS-MGUS). Data on patient characteristics, laboratory parameters at presentation, and clinical and laboratory outcomes were extracted.

Objectives

To describe the clinical presentation and outcomes of different therapeutic approaches.

Results

Seventy-five studies were included in the final review, for a total of 137 patients. Most patients had von Willebrand factor ristocetin cofactor activity <30 IU/dL (86.6

SUBMITTER: Abou-Ismail MY 

PROVIDER: S-EPMC7938620 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature