Targeting neurotrophic factors: Novel approaches to musculoskeletal pain.

ABSTRACT: Chronic pain represents a substantial unmet medical need globally. In recent years, the quest for a new generation of novel, safe, mechanism-based analgesic treatments has focused on neurotrophic factors, a large group of secreted proteins that control the growth and survival of different populations of neurons, but that postnatally are involved in the genesis and maintenance of pain, with biological activity in both the periphery and the central nervous system. In this narrative review, we discuss the two families of neurotrophic proteins that have been extensively studied for their role in pain: first, the neurotrophins, nerve growth factor (NGF) and brain-derived growth factor (BDNF), and secondly, the GDNF family of ligands (GFLs). We provide an overview of the pain pathway, and the pa

SUBMITTER: Malfait AM 

PROVIDER: S-EPMC7938761 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature