Effect of aspirin in vascular surgery in patients from a randomized clinical trial (POISE-2).

ABSTRACT:

Background

In the POISE-2 (PeriOperative ISchemic Evaluation 2) trial, perioperative aspirin did not reduce cardiovascular events, but increased major bleeding. There remains uncertainty regarding the effect of perioperative aspirin in patients undergoing vascular surgery. The aim of this substudy was to determine whether there is a subgroup effect of initiating or continuing aspirin in patients undergoing vascular surgery.

Methods

POISE-2 was a blinded, randomized trial of patients having non-cardiac surgery. Patients were assigned to perioperative aspirin or placebo. The primary outcome was a composite of death or myocardial infarction at 30 days. Secondary outcomes included: vascular occlusive complications (a composite of amputation and peripheral arterial thrombosis) an

SUBMITTER: Biccard BM 

PROVIDER: S-EPMC7938845 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature