Impact of ERCC2 Gene Polymorphisms on OSCC Susceptibility and Clinical Characteristics.

ABSTRACT: Background  DNA repair systems play an important role in maintaining the integrity of the human genome. Deficiency in the repair capacity due to either mutations or inherited polymorphisms in DNA repair genes may contribute to variations in the DNA repair capacity and subsequently susceptibility to cancer. Objectives  This study aimed to investigate the association between Excision repair cross-complementation groups 2 (ERCC2) single nucleotide polymorphisms (SNPs rs1799793 and rs13181) and the response to platinum-based chemotherapy among patients with oral squamous cell carcinoma (OSCC). Methodology  Polymerase chain reaction-based restriction fragment length polymorphism analysis was used to determine the polymorphism from a total of 150 OSCC patients and 150 normal

SUBMITTER: Tejasvi MA 

PROVIDER: S-EPMC7938941 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature