HIV-1 drug resistance before initiation or re-initiation of first-line ART in eight regions of Mexico: a sub-nationally representative survey.

ABSTRACT:

Background

HIV pretreatment drug resistance (PDR) to NNRTIs in persons initiating ART is increasing in Mexico.

Objectives

To compare HIV PDR in eight sub-regions of Mexico.

Patients and methods

A large PDR survey was implemented in Mexico (September 2017-March 2018) across eight sub-regions. All larger clinics (which provide ART to 90% of all initiators) were included, allocating sample size using the probability-proportional-to-size method. Both antiretroviral-naive and prior antiretroviral-exposed persons were included. HIV PDR levels were estimated from pol Sanger sequences obtained at a WHO-designated laboratory.

Results

A total of 2006 participants were enrolled from 74 clinics. PDR to NNRTIs was higher than to other drug classes (P < 0.0001), crossing the

SUBMITTER: Avila-Rios S 

PROVIDER: S-EPMC7939069 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature