MMP7 as a potential biomarker of colon cancer and its prognostic value by bioinformatics analysis.

ABSTRACT:

Abstract

Colon cancer is one of the most common cancers in the world. To identify the candidate genes in the carcinogenesis and progression of colon cancer, the microarray datasets GSE10950, GSE44861 and GSE74602 were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) were identified, and functional enrichment analyses were performed. A total of 176 DEGs were identified, consisting of 55 genes upregulated and 121 genes downregulated in colon cancer tissues compared to non-cancerous tissues. The DEGs were mainly enriched in mineral absorption, nitrogen metabolism and complement and coagulation cascades. By using STRING database analysis, we constructed a coexpression network composed of 140 nodes and 280 edges for the DEGs with a co

SUBMITTER: Chen L 

PROVIDER: S-EPMC7939218 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature