Analysis of Immune Gene Expression Subtypes Reveals Osteosarcoma Immune Heterogeneity.

ABSTRACT:

Background

Osteosarcoma (OS) patients have a poor response to immunotherapy due to the sheer complexity of the immune system and the nuances of the tumor-immune microenvironment. Methodology. To gain insights into the immune heterogeneity of OS, we identified robust clusters of patients based on the immune gene expression profiles of OS patients in the TARGET database and assessed their reproducibility in an independent cohort collected from the GEO database. The association of comprehensive molecular characterization with reproducible immune subtypes was accessed with ANOVA. Furthermore, we visualized the distribution of individual patients in a tree structure by the graph structure learning-based dimensionality reduction algorithm.

Results

We found that 87 OS sample

SUBMITTER: Wan B 

PROVIDER: S-EPMC7939746 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature