Biofilm-specific uptake of a 4-pyridone-based iron chelator by Pseudomonas aeruginosa.

ABSTRACT: Iron is an essential nutrient for virtually all microbes and limiting the concentration of available iron is a potential strategy to be used as an alternative to antibiotic treatment. In this study we analysed the antimicrobial activity of two chelators, specifically 3-hydroxy-1,2-dimethyl-4(1H)-pyridone (deferiprone, DFP), which is clinically approved for the treatment of iron overload disorders, and its 1,2-diethyl homologue, CP94. Both compounds showed moderate activity towards planktonically growing P. aeruginosa cells, and the mechanism of action of these chelators was indeed by limiting the amount of free iron. Surprisingly, the compounds behaved very differently when the cells were grown in biofilms. DFP also showed inhibitory effects on biofilm formation but in contrast, CP94 stimu

SUBMITTER: Houshmandyar S 

PROVIDER: S-EPMC7940164 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature