Targeted sequencing of Parkinson's disease loci genes highlights SYT11, FGF20 and other associations.

ABSTRACT: Genome-wide association studies (GWAS) have identified numerous loci associated with Parkinson's disease. The specific genes and variants that drive the associations within the vast majority of these loci are unknown. We aimed to perform a comprehensive analysis of selected genes to determine the potential role of rare and common genetic variants within these loci. We fully sequenced 32 genes from 25 loci previously associated with Parkinson's disease in 2657 patients and 3647 controls from three cohorts. Capture was done using molecular inversion probes targeting the exons, exon-intron boundaries and untranslated regions (UTRs) of the genes of interest, followed by sequencing. Quality control was performed to include only high-quality variants. We examined the role of rare variants (minor

SUBMITTER: Rudakou U 

PROVIDER: S-EPMC7940168 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature