Immune signature as predictive marker for response to checkpoint inhibitor immunotherapy and overall survival in melanoma.

ABSTRACT:

Background

Malignant melanoma is an immunogenic skin cancer with an increasing global incidence. Advanced stages of melanoma have poor prognoses. Currently, there are no reliable parameters to predict a patient's response to immune checkpoint inhibitor (ICI) therapy.

Methods

This study highlights the relevance of a distinct immune signature in the blood for response to ICI therapy and overall survival (OS). Therefore, the immune cell composition in the peripheral blood of 45 melanoma patients prior to ICI therapy was analyzed by flow cytometry and complete blood count.

Results

Responders to ICI therapy displayed an abundance of proliferating CD4⁺ T cells, an increased lymphocyte-to-monocyte ratio, a low platelet-to-lymphocyte ratio, low levels of CTLA-4

SUBMITTER: Krebs FK 

PROVIDER: S-EPMC7940230 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature