Pancreatic beta cell autophagy is impaired in type 1 diabetes.

ABSTRACT:

Aims/hypothesis

Pancreatic beta cells are subjected to exogenous damaging factors such as proinflammatory cytokines or excess glucose that can cause accumulation of damage-inducing reactive oxygen species during the pathogenesis of diabetes. We and others have shown that beta cell autophagy can reduce reactive oxygen species to protect against apoptosis. While impaired islet autophagy has been demonstrated in human type 2 diabetes, it is unknown if islet autophagy is perturbed in the pathogenesis of type 1 diabetes. We hypothesised that beta cell autophagy is dysfunctional in type 1 diabetes, and that there is a progressive loss during early diabetes development.

Methods

Pancreases were collected from chloroquine-injected and non-injected non-obese diabetes-resistant (NOR) a

SUBMITTER: Muralidharan C 

PROVIDER: S-EPMC7940272 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature