Oral drug delivery systems using core-shell structure additive manufacturing technologies: a proof-of-concept study.

ABSTRACT:

Objectives

The aim of this study was to couple fused deposition modelling 3D printing with melt extrusion technology to produce core-shell-structured controlled-release tablets with dual-mechanism drug-release performance in a simulated intestinal fluid medium. Coupling abovementioned technologies for personalized drug delivery can improve access to complex dosage formulations at a reasonable cost. Compared with traditional pharmaceutical manufacturing, this should facilitate the following: (1) the ability to manipulate drug release by adjusting structures, (2) enhanced solubility and bioavailability of poorly water-soluble drugs and (3) on-demand production of more complex structured dosages for personalized treatment.

Methods

Acetaminophen was the model drug and the extrus

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7940344 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature