Comparison of Selective Versus Empiric Pharmacologic Preventative Therapy With Kidney Stone Recurrence.

ABSTRACT:

Objective

To assess the effectiveness of an empiric approach to metabolic stone prevention.

Methods

Using medical claims from a cohort of working age adults with kidney stone diagnoses (2008-2017), we identified the subset who were prescribed thiazides, alkali therapy, or allopurinol-collectively known as preventive pharmacologic therapy (PPT). We distinguished between those who had 24-hour urine testing prior to initiating PPT (selective therapy) from those without it (empiric therapy). We conducted a survival analysis for time to first recurrence for stone-related events, including ED visits, hospitalizations, and surgery, up to 2 years after initiating PPT.

Results

Of 10,125 patients identified, 2744 (27%) and 7381 (73%) received selective and empiric therapy, resp

SUBMITTER: Hsi RS 

PROVIDER: S-EPMC7940562 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature