Regulatory Cell Therapy in Organ Transplantation: Achievements and Open Questions.

ABSTRACT: The effective development of innovative surgical applications and immunosuppressive agents have improved remarkable advancements in solid organ transplantation. Despite these improvements led to prevent acute rejection and to promote short-term graft survival, the toxicity of long-term immunosuppression regiments has been associated to organ failure or chronic graft rejection. The graft acceptance is determined by the balance between the regulatory and the alloreactive arm of the immune system. Hence, enhance regulatory cells leading to immune tolerance would be the solution to improve long-term allograft survival which, by reducing the overall immunosuppression, will provide transplanted patients with a better quality of life. Regulatory T cells (Tregs), and regulatory myeloid cells (MRCs

SUBMITTER: Fortunato M 

PROVIDER: S-EPMC7940680 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature