Analysis and Validation of circRNA-miRNA Network in Regulating m⁶A RNA Methylation Modulators Reveals CircMAP2K4/miR-139-5p/YTHDF1 Axis Involving the Proliferation of Hepatocellular Carcinoma.

ABSTRACT: The m⁶A RNA methylation modulators play a crucial role in regulating hepatocellular carcinoma (HCC) progression. The circular RNA (circRNA) regulatory network in regulating m⁶A RNA methylation modulators in HCC remains largely unknown. In this study, 5 prognostic m⁶A RNA methylation modulators in HCC were identified from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) projects. The differentially expressed microRNAs (DEmiRNAs) and circRNAs (DEcircRNAs) between paired tumor and normal tissues were screened out from TCGA and or Gene Expression Omnibus (GEO) database to construct the circRNA-miRNA- m⁶A RNA methylation modulator regulatory network, which included three m⁶A RNA methylation modulators (HNRNPC

SUBMITTER: Chi F 

PROVIDER: S-EPMC7940687 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature