Oncolytic herpes simplex virus infects myeloma cells in vitro and in vivo.

ABSTRACT: Because most patients with multiple myeloma (MM) develop resistance to current regimens, novel approaches are needed. Genetically modified, replication-competent oncolytic viruses exhibit high tropism for tumor cells regardless of cancer stage and prior treatment. Receptors of oncolytic herpes simplex virus 1 (oHSV-1), NECTIN-1, and HVEM are expressed on MM cells, prompting us to investigate the use of oHSV-1 against MM. Using oHSV-1-expressing GFP, we found a dose-dependent increase in the GFP⁺ signal in MM cell lines and primary MM cells. Whereas NECTIN-1 expression is variable among MM cells, we discovered that HVEM is ubiquitously and highly expressed on all samples tested. Expression of HVEM was consistently higher on CD138⁺/CD38⁺ plasma cells than in

SUBMITTER: Ghose J 

PROVIDER: S-EPMC7940704 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature