Decreased plasma musclin levels are associated with potential atrial fibrillation in non-diabetic patients.

ABSTRACT:

Background

Musclin is involved in the regulation of natriuretic peptide (NP) clearance and may affect the concentration of atrial natriuretic peptide (ANP). It has also been found to play an important role in several diseases, such as diabetes mellitus and hypertension. Both abnormalities in ANP and associated medical history are involved in the pathogenesis of atrial fibrillation (AF). However, plasma concentration of musclin as a biomarker for risk stratification in patients with AF has not been fully investigated.

Methods

Plasma musclin levels were measured in 290 patients with AF (including 199 paroxysmal AF patients and 91 persistent AF patients) and 120 control subjects. The association between plasma musclin levels and AF onset, as well as its predictive effects on cl

SUBMITTER: Zhong Y 

PROVIDER: S-EPMC7940914 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature