Effects of continuous venovenous hemofiltration on vancomycin trough concentrations in critically ill children.

ABSTRACT:

Background

Vancomycin trough concentrations are associated with clinical outcomes and drug adverse effects. This study investigates the effects of continuous venovenous hemofiltration (CVVH) on vancomycin trough concentrations in critically ill children with a vancomycin dosage of 40-60 mg/kg/day.

Methods

Children with steady-state vancomycin trough concentrations admitted to the pediatric intensive care unit (PICU) between January 2016 and December 2019 were retrospectively enrolled. Patients were divided into CVVH and non-CVVH groups according to treatment differences and renal function. Vancomycin trough concentrations were then compared between the groups, and risk factors for supratherapeutic trough concentrations (>20 mg/L) were analyzed with logistic regression.

Re

SUBMITTER: Peng L 

PROVIDER: S-EPMC7940948 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature