Identification of key pathways and core genes involved in atherosclerotic plaque progression.

ABSTRACT:

Background

Atherosclerosis leads to the occurrence of cardiovascular diseases. However, the molecular mechanisms that contribute to atherosclerotic plaque rupture are incompletely characterized. We aimed to identify the genes related to atherosclerotic plaque progression that could serve as novel biomarkers and interventional targets for plaque progression.

Methods

The datasets of GSE28829 in early vs. advanced atherosclerotic plaques and those of GSE41571 in stable vs. ruptured plaques from Gene Expression Omnibus (GEO) were analyzed by using bioinformatics methods. In addition, we used quantitative reverse transcription polymerase chain reaction (qRT-PCR) to verify the expression level of core genes in a mouse atherosclerosis model.

Results

There were

SUBMITTER: Yang R 

PROVIDER: S-EPMC7940950 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature