Development of a core outcome set for clinical trials aimed at improving antimicrobial stewardship in care homes.

ABSTRACT:

Background

Diverse outcomes reported in clinical trials of antimicrobial stewardship (AMS) interventions in care homes have hindered evidence synthesis. Our main objective was to develop a core outcome set (COS) for use in trials aimed at improving AMS in care homes.

Methods

A refined inventory of outcomes for AMS interventions in care homes, compiled from a previous study, was rated in a three-round international Delphi survey with 82 participants, using a nine-point Likert scale (from 1, unimportant, to 9, critical). This was followed by an online consensus exercise with 12 participants from Northern Ireland to finalise the COS content. Subsequently, a suitable outcome measurement instrument (OMI) was selected for each outcome in the COS by: identifying existing OMIs throu

SUBMITTER: Nguyen HQ 

PROVIDER: S-EPMC7941135 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature