Growth differentiation factor 5 in cartilage and osteoarthritis: A possible therapeutic candidate.

ABSTRACT: Growth differentiation factor 5 (GDF-5) is essential for cartilage development and homeostasis. The expression and function of GDF-5 are highly associated with the pathogenesis of osteoarthritis (OA). OA, characterized by progressive degeneration of joint, particularly in cartilage, causes severe social burden. However, there is no effective approach to reverse the progression of this disease. Over the past decades, extensive studies have demonstrated the protective effects of GDF-5 against cartilage degeneration and defects. Here, we summarize the current literature describing the role of GDF-5 in development of cartilage and joints, and the association between the GDF-5 gene polymorphisms and OA susceptibility. We also shed light on the protective effects of GDF-5 against OA in terms of

SUBMITTER: Sun K 

PROVIDER: S-EPMC7941218 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature