Polymorphism and surface diversity arising from stress-induced transformations – the case of multicomponent forms of carbamazepine

ABSTRACT: Labile multicomponent crystal forms of carbamazepine have been studied with an aim of identifying the structural and surface features that drive the outcome of thermal stress-induced transformations. Stress-induced transformations of labile multicomponent organic solids may have a significant impact on industrial manufacturing processes, for example, in the pharmaceutical field. This study considers 15 carbamazepine (CBZ) multicomponent crystal forms, with the aim of identifying the structural and surface features that drive the outcome of thermal stress-induced transformations. Analysis of the crystal structures, and specifically the degree of similarity with the CBZ polymorphs produced by desolvation-like processes, identifies some degree of correlation between structural features. In pa

SUBMITTER: Schneider-Rauber G 

PROVIDER: S-EPMC7941281 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature