Expression of human papillomavirus oncoproteins E6 and E7 inhibits invadopodia activity but promotes cell migration in HPV-positive head and neck squamous cell carcinoma cells.

ABSTRACT:

Background

The rapid increase in the incidence of head and neck squamous cell carcinoma (HNSCC) is caused by high-risk human papillomavirus (HPV) infections. The HPV oncogenes E6 and E7 promote carcinogenesis by disrupting signaling pathways that control survival and proliferation. Although these cancers are often diagnosed with metastases, the mechanisms that regulate their dissemination are unknown.

Aims

The aim of this study was to determine whether the HPV-16 E6 and E7 oncogenes affected the invasive and migratory properties of HNSCC cells which promote their spread and metastasis.

Methods and results

Invasiveness was determined using invadopodia assays which allow for quantitation of extracellular matrix (ECM) degradation by invadopodia which are proteolytic memb

SUBMITTER: Kahue CN 

PROVIDER: S-EPMC7941430 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature