Comparison of prostate-specific membrane antigen ligands in clinical translation research for diagnosis of prostate cancer.

ABSTRACT:

Background

Prostate-specific membrane antigen (PSMA), overexpressed on prostate cancer (PCa), is a well-characterized cell surface protein to selectively diagnose PCa. PSMA's unique characteristics and its 1000-fold higher expression in PCa compared with other tissues renders it as a suitable biomarker for detection of PCa in its early stage. In this report, we critically analyze and recommend the requirements needed for the development of variety of PSMA-targeted molecular imaging agents based on antibodies, small molecule ligands, peptides, and aptamers. The targeting moieties are either conjugated to radionuclear isotopes or near-infrared agents for efficient diagnosis of PCa.

Recent findings

From the analysis, it was found that several small molecule-derived PCa imaging

SUBMITTER: Sengupta S 

PROVIDER: S-EPMC7941450 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature