The RS4;11 cell line as a model for leukaemia with t(4;11)(q21;q23): Revised characterisation of cytogenetic features.

ABSTRACT:

Background

Haematological malignancies harbouring rearrangements of the KMT2A gene represent a unique subtype of leukaemia, with biphenotypic clinical manifestations, a rapid and aggressive onset, and a generally poor prognosis. Chromosomal translocations involving KMT2A often cause the formation of oncogenic fusion genes, such as the most common translocation t(4;11)(q21;q23) producing the KMT2A-AFF1 chimera.

Aim

The aim of this study was to confirm and review the cytogenetic and molecular features of the KMT2A-rearranged RS4;11 cell line and put those in context with other reports of cell lines also harbouring a t(4;11) rearrangement.

Methods and results

The main chromosomal rearrangements t(4;11)(q21;q23) and i(7q), described when the cell line was first establishe

SUBMITTER: Ragusa D 

PROVIDER: S-EPMC7941496 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature