Dataset Information

Negligible impact of SARS-CoV-2 variants on CD4 + and CD8 + T cell reactivity in COVID-19 exposed donors and vaccinees.

ABSTRACT: The emergence of SARS-CoV-2 variants highlighted the need to better understand adaptive immune responses to this virus. It is important to address whether also CD4+ and CD8+ T cell responses are affected, because of the role they play in disease resolution and modulation of COVID-19 disease severity. Here we performed a comprehensive analysis of SARS-CoV-2-specific CD4+ and CD8+ T cell responses from COVID-19 convalescent subjects recognizing the ancestral strain, compared to variant lineages B.1.1.7, B.1.351, P.1, and CAL.20C as well as recipients of the Moderna (mRNA-1273) or Pfizer/BioNTech (BNT162b2) COVID-19 vaccines. Similarly, we demonstrate that the sequences of the vast majority of SARS-CoV-2 T cell epitopes are not affected by the mutations found in the variants analyzed. Overall, the results demonstrate that CD4+ and CD8+ T cell responses in convalescent COVID-19 subjects or COVID-19 mRNA vaccinees are not substantially affected by mutations found in the SARS-CoV-2 variants.

SUBMITTER: Tarke A

PROVIDER: S-EPMC7941626 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Negligible impact of SARS-CoV-2 variants on CD4 <sup>+</sup> and CD8 <sup>+</sup> T cell reactivity in COVID-19 exposed donors and vaccinees.

Tarke Alison A Sidney John J Methot Nils N Zhang Yun Y Dan Jennifer M JM Goodwin Benjamin B Rubiro Paul P Sutherland Aaron A da Silva Antunes Ricardo R Frazier April A Rawlings Stephen A SA Smith Davey M DM Peters Bjoern B Scheuermann Richard H RH Weiskopf Daniela D Crotty Shane S Grifoni Alba A Sette Alessandro A

bioRxiv : the preprint server for biology 20210301

The emergence of SARS-CoV-2 variants highlighted the need to better understand adaptive immune responses to this virus. It is important to address whether also CD4+ and CD8+ T cell responses are affected, because of the role they play in disease resolution and modulation of COVID-19 disease severity. Here we performed a comprehensive analysis of SARS-CoV-2-specific CD4+ and CD8+ T cell responses from COVID-19 convalescent subjects recognizing the ancestral strain, compared to variant lineages B. ...[more]

PMID: 33688655

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Dataset Information

Negligible impact of SARS-CoV-2 variants on CD4 + and CD8 + T cell reactivity in COVID-19 exposed donors and vaccinees.

Publications

Negligible impact of SARS-CoV-2 variants on CD4 <sup>+</sup> and CD8 <sup>+</sup> T cell reactivity in COVID-19 exposed donors and vaccinees.

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