Mathematical modeling to inform vaccination strategies and testing approaches for COVID-19 in nursing homes.

ABSTRACT: Nursing home residents and staff were included in the first phase of COVID-19 vaccination in the United States. Because the primary trial endpoint was vaccine efficacy (VE) against symptomatic disease, there are limited data on the extent to which vaccines protect against SARS-CoV-2 infection and the ability to infect others (infectiousness). Assumptions about VE against infection and infectiousness have implications for possible changes to infection prevention guidance for vaccinated populations, including testing strategies. We use a stochastic agent-based SEIR model of a nursing home to simulate SARS-CoV-2 transmission. We model three scenarios, varying VE against infection, infectiousness, and symptoms, to understand the expected impact of vaccination in nursing homes, increasing staff

SUBMITTER: Kahn R 

PROVIDER: S-EPMC7941643 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature