Y-LineageTracker: a high-throughput analysis framework for Y-chromosomal next-generation sequencing data.

ABSTRACT:

Background

Y-chromosome DNA (Y-DNA) has been used for tracing paternal lineages and offers a clear path from an individual to a known, or likely, direct paternal ancestor. The advance of next-generation sequencing (NGS) technologies increasingly improves the resolution of the non-recombining region of the Y-chromosome (NRY). However, a lack of suitable computer tools prevents the use of NGS data from the Y-DNA studies.

Results

We developed Y-LineageTracker, a high-throughput analysis framework that not only utilizes state-of-the-art methodologies to automatically determine NRY haplogroups and identify microsatellite variants of Y-chromosome on a fine scale, but also optimizes comprehensive Y-DNA analysis methods for NGS data. Notably, Y-LineageTracker integrates the NRY hapl

SUBMITTER: Chen H 

PROVIDER: S-EPMC7941695 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature