Baseline liver steatosis has no impact on liver metastases and overall survival in rectal cancer patients.

ABSTRACT:

Background

The liver is one of the most frequent sites of metastases in rectal cancer. This study aimed to evaluate how the development of synchronous or metachronous liver metastasis and overall survival are impacted by baseline liver steatosis and chemotherapy-induced liver damage in rectal cancer patients.

Methods

Patients diagnosed with stage II to IV rectal cancer between 2010 and 2016 in our province with suitable baseline CT scan were included. Data on cancer diagnosis, staging, therapy, outcomes and liver function were collected. CT scans were retrospectively reviewed to assess baseline steatosis (liver density < 48 HU and/or liver-to-spleen ratio < 1.1). Among patients without baseline steatosis and treated with neoadjuvant chemotherapy, chemotherapy-induced liver d

SUBMITTER: Besutti G 

PROVIDER: S-EPMC7941741 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature