Recent Advances in Clinical Translation of Intra-Articular Osteoarthritis Drug Delivery Systems.

ABSTRACT: Osteoarthritis (OA) is a degenerative disease of the joints and a leading cause of physical disability in adults. Intra-articular (IA) therapy is a popular treatment strategy for localized, single-joint OA; however, small-molecule drugs such as corticosteroids do not provide prolonged relief. One possible reason for their lack of efficacy is high clearance rates from the joint through constant lymphatic drainage of the synovial tissues and synovial fluid and also by their exchange via the synovial vasculature. Advanced drug delivery strategies for extended release of therapeutic agents in the joint space is a promising approach to improve outcomes for OA patients. Broadly, the basic principle behind this strategy is to encapsulate therapeutic agents in a polymeric drug delivery system (DDS

SUBMITTER: DeJulius CR 

PROVIDER: S-EPMC7941755 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature