Birth weight and perfluorooctane sulfonic acid: a random-effects meta-regression analysis.

ABSTRACT: Perfluorooctane sulfonic acid (PFOS) is a ubiquitous environmental contaminant. Most people in developed countries have detectable serum concentrations. Lower birth weight has been associated with serum PFOS in studies world-wide, many of which have been published only recently.

Methods

To facilitate a causal assessment of the birth weight and PFOS association, we updated previous meta-analyses of the association and employed a method that facilitated inclusion of all available data in one analysis. Our analysis was based on observations from 29 studies.

Results

The random effects summary was -3.22 g/ng/ml (95% confidence interval [CI] = -5.11, -1.33). In a subgroup analysis stratified by when in pregnancy the PFOS concentration was measured, the summary for the early group w

SUBMITTER: Dzierlenga MW 

PROVIDER: S-EPMC7941775 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature