Dysbiosis of gut microbiota and its correlation with dysregulation of cytokines in psoriasis patients.

ABSTRACT:

Background

Psoriasis is an inflammatory skin disease associated with multiple comorbidities and substantially diminishes patients' quality of life. The gut microbiome has become a hot topic in psoriasis as it has been shown to affect both allergy and autoimmunity diseases in recent studies. Our objective was to identify differences in the fecal microbial composition of patients with psoriasis compared with healthy individuals to unravel the microbiota profiling in this autoimmune disease.

Results

We collected fecal samples from 30 psoriasis patients and 30 healthy controls, sequenced them by 16S rRNA high-throughput sequencing, and identified the gut microbial composition using bioinformatic analyses including Quantitative Insights into Microbial Ecology (QIIME) and Phylogen

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7941898 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature