CAMP activates calcium signalling via phospholipase C to regulate cellulase production in the filamentous fungus Trichoderma reesei.

ABSTRACT:

Background

The filamentous fungus Trichoderma reesei is one of the best producers of cellulase and has been widely studied for the production of cellulosic ethanol and bio-based products. We previously reported that Mn²⁺ and N,N-dimethylformamide (DMF) can stimulate cellulase overexpression via Ca²⁺ bursts and calcium signalling in T. reesei under cellulase-inducing conditions. To further understand the regulatory networks involved in cellulase overexpression in T. reesei, we characterised the Mn²⁺/DMF-induced calcium signalling pathway involved in the stimulation of cellulase overexpression.

Results

We found that Mn²⁺/DMF stimulation significantly increased the intracellular levels of cAMP in an adenylate cyclase (ACY1)-dependent

SUBMITTER: Chen Y 

PROVIDER: S-EPMC7941909 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature