Dataset Information

The importance of CDC27 in cancer: molecular pathology and clinical aspects.

ABSTRACT:

Background

CDC27 is one of the core components of Anaphase Promoting complex/cyclosome. The main role of this protein is defined at cellular division to control cell cycle transitions. Here we review the molecular aspects that may affect CDC27 regulation from cell cycle and mitosis to cancer pathogenesis and prognosis.

Main text

It has been suggested that CDC27 may play either like a tumor suppressor gene or oncogene in different neoplasms. Divergent variations in CDC27 DNA sequence and alterations in transcription of CDC27 have been detected in different solid tumors and hematological malignancies. Elevated CDC27 expression level may increase cell proliferation, invasiveness and metastasis in some malignancies. It has been proposed that CDC27 upregulation may increase stemness in cancer stem cells. On the other hand, downregulation of CDC27 may increase the cancer cell survival, decrease radiosensitivity and increase chemoresistancy. In addition, CDC27 downregulation may stimulate efferocytosis and improve tumor microenvironment.

Conclusion

CDC27 dysregulation, either increased or decreased activity, may aggravate neoplasms. CDC27 may be suggested as a prognostic biomarker in different malignancies.

SUBMITTER: Kazemi-Sefat GE

PROVIDER: S-EPMC7941923 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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The importance of CDC27 in cancer: molecular pathology and clinical aspects.

Kazemi-Sefat Golnaz Ensieh GE Keramatipour Mohammad M Talebi Saeed S Kavousi Kaveh K Sajed Roya R Kazemi-Sefat Nazanin Atieh NA Mousavizadeh Kazem K

Cancer cell international 20210309 1

<h4>Background</h4>CDC27 is one of the core components of Anaphase Promoting complex/cyclosome. The main role of this protein is defined at cellular division to control cell cycle transitions. Here we review the molecular aspects that may affect CDC27 regulation from cell cycle and mitosis to cancer pathogenesis and prognosis.<h4>Main text</h4>It has been suggested that CDC27 may play either like a tumor suppressor gene or oncogene in different neoplasms. Divergent variations in CDC27 DNA sequen ...[more]

PMID: 33750395

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Dataset Information

The importance of CDC27 in cancer: molecular pathology and clinical aspects.

Background

Main text

Conclusion

Publications

The importance of CDC27 in cancer: molecular pathology and clinical aspects.

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