Association between ALDH2 polymorphism and esophageal cancer risk in South Koreans: a case-control study.

ABSTRACT:

Background

Alcohol consumption is a major risk factor for esophageal cancer; however, a high incidence of esophageal cancer is observed particularly among Eastern Asians, although they consume relatively less alcohol, presumably due to the high frequency of aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphisms. Nevertheless, the association between ALDH2 polymorphisms and esophageal cancer remains under debate. In the present study, we evaluated the association between ALDH2 rs671 polymorphisms and the risk of esophageal cancer in the South Korean population.

Methods

This study included 783 hospital based-cases and 8732 population-based controls. Information on smoking history and alcohol consumption was obtained from the medical records or interview questionnaires. Age-adjus

SUBMITTER: Choi CK 

PROVIDER: S-EPMC7941978 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature