Effects of living kidney donation on arterial stiffness: a systematic review protocol.

ABSTRACT:

Introduction

Kidney donors have been reported to have accelerated progression of aortic stiffness and decreased glomerular filtration compared with healthy non-donors. This is a concern because increased aortic stiffness is an independent predictor of overall cardiovascular disease and all-cause mortality in the general population. To confirm if arterial stiffness increases after donation, we will systematically review all studies that evaluated indices of arterial stiffness in healthy individuals who underwent unilateral nephrectomy for kidney donation compared with age-matched healthy non-nephrectomised controls.

Methods/analysis

We will comprehensively search for studies published between 1 January 1960 and 15 March 2021 in MEDLINE, EMBASE, Cochrane Central, OVID and EBM

SUBMITTER: Rodriguez RA 

PROVIDER: S-EPMC7942241 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature