Identification of a Novel Serum Proteomic Signature for Primary Sjogren's Syndrome.

ABSTRACT:

Context

Primary Sjögren's syndrome (pSS) is a complex heterogeneous autoimmune disease (AID) which can mimic rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). Our exploratory study investigated serum biomarkers that may discriminate pSS from RA and SLE.

Methods

Serum concentrations of 63 biomarkers involved in immune cell trafficking, inflammatory response, cellular movement, and cell-to-cell signaling were measured in AID patients, included prospectively into the study at the Montpellier University Hospital. A multivariate analysis by multiple logistic regression was performed, and discriminative power assessed using logistic regression adjusted on significant demographic factors.

Results

Among the 95 patients enrolled, 42 suffered from pSS, 28 from RA

SUBMITTER: Padern G 

PROVIDER: S-EPMC7942395 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature