Prognostic Value and Biological Functions of RNA Binding Proteins in Stomach Adenocarcinoma.

ABSTRACT:

Purpose

To investigate the prognostic value and biological function of RNA binding proteins (RBPs) in stomach adenocarcinoma (STAD).

Materials and methods

Datasets of the differentially expressed genes (DEGs) were downloaded from the TCGA-based (The Cancer Genome Atlas) GEPIA database, from which the differentially expressed RBPs were determined. Functions and prognostic values of these determined RBPs were systematically investigated by a series of methods in bioinformatics analysis. In addition, transwell assays were performed to explore the effect of PTBP1 in STAD cells.

Results

Three hundred and sixty-two differentially expressed RBPs were determined, with 331 up-regulated and 31 down-regulated. Seven RBPs (PTBP1, PPIH, SMAD5, MSI2, RBM15, MRPS17, and AD

SUBMITTER: Li J 

PROVIDER: S-EPMC7942957 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature