Probing the structure of nanodiscs using surface-induced dissociation mass spectrometry.
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ABSTRACT:
SUBMITTER: Harvey SR
PROVIDER: S-EPMC7943047 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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Probing the structure of nanodiscs using surface-induced dissociation mass spectrometry.
Harvey Sophie R SR VanAernum Zachary L ZL Kostelic Marius M MM Marty Michael T MT Wysocki Vicki H VH
Chemical communications (Cambridge, England) 20201208 100
In the study of membrane proteins and antimicrobial peptides, nanodiscs have emerged as a valuable membrane mimetic to solubilze these molecules in a lipid bilayer. We present the structural characterization of nanodiscs using native mass spectrometry and surface-induced dissociation, which are powerful tools in structural biology. ...[more]
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