Metabolites and metabolic pathways associated with glucocorticoid resistance in pregnant African-American women.

ABSTRACT: Glucocorticoid resistance (GR) is associated with exposure to chronic stress and an increased risk of metabolic and inflammatory disorders in both animal and human populations. Studies on ethnic disparities highlight the African-American (AA) population as having a high propensity to both GR and chronic stress exposure. Glucocorticoids and inflammation play a very important role in pregnancy outcome and fetal development. To date, however, the metabolites and metabolic pathways associated with GR during pregnancy have not been identified, obscuring the mechanisms by which adverse health consequences arise, and thus impeding targeted therapeutic intervention. The objective of this study was to perform untargeted high-resolution metabolomics (HRM) profiling on 273 pregnant AA women, to ident

SUBMITTER: Corwin E 

PROVIDER: S-EPMC7943062 | biostudies-literature | 2020 Feb-May

REPOSITORIES: biostudies-literature