Maternal exposure to PM_2.5 during pregnancy and asthma risk in early childhood: consideration of phases of fetal lung development.

ABSTRACT:

Background

Increasingly studies suggest prenatal exposure to air pollution may increase risk of childhood asthma. Few studies have investigated exposure during specific fetal pulmonary developmental windows.

Objective

To assess associations between prenatal fine particulate matter exposure and asthma at age 4.

Methods

This study included mother-child dyads from two pregnancy cohorts-CANDLE and TIDES-within the ECHO-PATHWAYS consortium (births in 2007-2013). Three child asthma outcomes were parent-reported: ever asthma, current asthma, and current wheeze. Fine particulate matter (PM_2.5) exposures during the pseudoglandular (5-16 weeks gestation), canalicular (16-24 weeks gestation), saccular (24-36 weeks gestation), and alveolar (36+ weeks gestation) phases

SUBMITTER: Hazlehurst MF 

PROVIDER: S-EPMC7943175 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature