Fiber engraving for bioink bioprinting within 3D printed tissue engineering scaffolds.

ABSTRACT: In this work, we describe a new 3D printing methodology for the fabrication of multimaterial scaffolds involving the combination of thermoplastic extrusion and low temperature extrusion of bioinks. A fiber engraving technique was used to create a groove on the surface of a thermoplastic printed fiber using a commercial 3D printer and a low viscosity bioink was deposited into this groove. In contrast to traditional extrusion bioinks that rely on increased viscosity to prevent lateral spreading, this groove creates a defined space for bioink deposition. By physically constraining bioink spreading, a broader range of viscosities can be used. As proof-of-concept, we fabricated and characterized a multimaterial scaffold containing poly(ε-caprolactone) (PCL) as the thermoplastic polymer and a ge

SUBMITTER: Diaz-Gomez L 

PROVIDER: S-EPMC7943183 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature