Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system.
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ABSTRACT:
SUBMITTER: Icke C
PROVIDER: S-EPMC7943197 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system.
Icke Christopher C Hodges Freya J FJ Pullela Karthik K McKeand Samantha A SA Bryant Jack Alfred JA Cunningham Adam F AF Cole Jeff A JA Henderson Ian R IR
eLife 20210224
Protein acylation is critical for many cellular functions across all domains of life. In bacteria, lipoproteins have important roles in virulence and are targets for the development of antimicrobials and vaccines. Bacterial lipoproteins are secreted from the cytosol via the Sec pathway and acylated on an N-terminal cysteine residue through the action of three enzymes. In Gram-negative bacteria, the Lol pathway transports lipoproteins to the outer membrane. Here, we demonstrate that the Aat secre ...[more]
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