Salivary CCL20 Level as a Biomarker for Oral Squamous Cell Carcinoma.

ABSTRACT:

Background/aim

This study investigated the utility of C-C motif chemokine ligand 20 (CCL20) expression in saliva as a biomarker for oral squamous cell carcinoma (OSCC) and also examined the associated microbiome.

Materials and methods

The study group included patients with OSCC or oral potentially malignant disorder (OPMD), and healthy volunteers (HVs). microarray and qRT-PCR were used to compare salivary CCL20 expression levels among groups. Data on CCL20 levels in oral cancer tissues and normal tissues were retrieved from a public database and examined. Furthermore, next-generation sequencing was used to investigate the salivary microbiome.

Results

A significant increase in the expression level of CCL20 was observed in both OSCC tissues and saliva from patients with

SUBMITTER: Ueda S 

PROVIDER: S-EPMC7943213 | biostudies-literature | 2021 Mar-Apr

REPOSITORIES: biostudies-literature