Both beat-to-beat changes in RR-interval and left ventricular filling time determine ventricular function during atrial fibrillation.

ABSTRACT:

Aims

The irregular atrial electrical activity during atrial fibrillation (AF) is associated with a variable left ventricular (LV) systolic function. The mechanisms determining LV function during AF remain incompletely understood. We aimed at elucidating how changes in RR-interval and LV preload affect LV function during AF.

Methods and results

Beat-to-beat speckle-tracking echocardiography was performed in 10 persistent AF patients. We evaluated the relation between longitudinal LV peak strain and preceding RR-interval during AF. We used the CircAdapt computational model to evaluate beat-to-beat preload and peak strain during AF for each patient by imposing the patient-specific RR-interval sequences and a non-contractile atrial myocardium. Generic simulations with artificial

SUBMITTER: Lyon A 

PROVIDER: S-EPMC7943365 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature