Hippocampal subfield alterations in pediatric patients with post-traumatic stress disorder.

ABSTRACT: The hippocampus, a key structure with distinct subfield functions, is strongly implicated in the pathophysiology of post-traumatic stress disorder (PTSD); however, few studies of hippocampus subfields in PTSD have focused on pediatric patients. We therefore investigated the hippocampal subfield volume using an automated segmentation method and explored the subfield-centered functional connectivity aberrations related to the anatomical changes, in a homogenous population of traumatized children with and without PTSD. To investigate the potential diagnostic value in individual patients, we used a machine learning approach to identify features with significant discriminative power for diagnosis of PTSD using random forest classifiers. Compared to controls, we found significant mean volume red

SUBMITTER: Li L 

PROVIDER: S-EPMC7943370 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature