Ontology highlight
ABSTRACT:
SUBMITTER: Zhao H
PROVIDER: S-EPMC7943568 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Zhao Hanjun H To Kelvin K W KKW Lam Hoiyan H Zhou Xinxin X Chan Jasper Fuk-Woo JF Peng Zheng Z Lee Andrew C Y ACY Cai Jianpiao J Chan Wan-Mui WM Ip Jonathan Daniel JD Chan Chris Chung-Sing CC Yeung Man Lung ML Zhang Anna Jinxia AJ Chu Allen Wing Ho AWH Jiang Shibo S Yuen Kwok-Yung KY
Nature communications 20210309 1
Up to date, effective antivirals have not been widely available for treating COVID-19. In this study, we identify a dual-functional cross-linking peptide 8P9R which can inhibit the two entry pathways (endocytic pathway and TMPRSS2-mediated surface pathway) of SARS-CoV-2 in cells. The endosomal acidification inhibitors (8P9R and chloroquine) can synergistically enhance the activity of arbidol, a spike-ACE2 fusion inhibitor, against SARS-CoV-2 and SARS-CoV in cells. In vivo studies indicate that 8 ...[more]