Performance characteristics and costs of serological tests for brucellosis in a pastoralist community of northern Tanzania.

ABSTRACT: The control of brucellosis across sub-Saharan Africa is hampered by the lack of standardized testing and the use of tests with poor performance. This study evaluated the performance and costs of serological assays for human brucellosis in a pastoralist community in northern Tanzania. Serum collected from 218 febrile hospital patients was used to evaluate the performance of seven index tests, selected based on international recommendation or current use. We evaluated the Rose Bengal test (RBT) using two protocols, four commercial agglutination tests and a competitive enzyme-linked immunosorbent assay (cELISA). The sensitivity, specificity, positive predictive value, negative predictive value, Youden's index, diagnostic accuracy, and per-sample cost of each index test were estimated. The dia

SUBMITTER: Lukambagire AS 

PROVIDER: S-EPMC7943594 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature